Botika Botanika Highland Dandelion Liver Flush Tabs (1g)

Botika Botanika Highland Dandelion Liver Flush Tabs (1g) feature Taraxacum mongolicum, a species recognized in Traditional Chinese Medicine (TCM) and Western herbalism for its hepatobiliary benefits. Harvested from the nutrient-rich soils of Philippine highland regions, this formulation targets liver stagnation, heat accumulation, and water retention, conditions traditionally associated with poor digestion, fatigue, and dermal congestion.

The root is rich in sesquiterpene lactones, inulin, choline, and phenolic acids—compounds known to stimulate bile secretion, hepatic enzyme activity, and diuretic elimination. In TCM, dandelion (Pu Gong Ying) is used to clear heat and toxins, particularly in liver, gallbladder, and gastrointestinal disorders.

This 1g tablet is a pure dehydrated root press, designed for daily liver hygiene and gentle detoxification. Through Botika Botanika’s validated slow-curing dehydration method, enzyme activity is preserved while bitterness is retained to stimulate taste-receptor-mediated hepatic reflexes.

Indications may include:

Mild to moderate fatty liver or digestive stagnation

Skin conditions linked to internal heat (e.g. acne, boils)

Mild edema, bloating, or water weight retention

Post-antibiotic liver strain or general hepatic support

This formulation reflects Botika Botanika’s ethnopharmacological discipline, combining classical theory with organ-specific phytochemistry to deliver a trusted liver companion for both seasonal and long-term use.

Pharmacokinetics

Absorption:

Dandelion root contains phenolic acids (e.g., chicoric acid, caffeic acid), inulin-type fructans, taraxasterol, and sesquiterpene lactones. Upon oral ingestion, phenolic acids are absorbed through active transport (e.g., MCT1, SLC22A) in the duodenum and jejunum, reaching peak plasma levels within 1–2 hours. Inulin, a soluble fiber, resists digestion and reaches the colon intact where it undergoes fermentation by gut microbiota, producing short-chain fatty acids (SCFAs). Lipophilic compounds like taraxasterol undergo micelle formation and lymphatic transport, similar to fat-soluble vitamins.

Distribution:

Once absorbed, phenolic acids circulate as free acids and conjugated forms (e.g., sulfates, glucuronides), distributing primarily to the liver, kidneys, and intestinal mucosa. Inulin fermentation products influence hepatoportal blood chemistry and improve colonocyte energy metabolism. Taraxasterol binds weakly to plasma proteins but concentrates in hepatic and biliary tissues.

Metabolism:

Most caffeic and chicoric acids undergo phase II biotransformation (glucuronidation/sulfation) in the liver and intestines. Microbial metabolism of inulin yields acetate, butyrate, and propionate, which enter systemic circulation and influence hepatic gene expression, lipid regulation, and gut barrier function. Bitter triterpenes (e.g., taraxasterol) are partly hydroxylated in hepatic microsomes, contributing to cytochrome P450 modulation.

Elimination:

Metabolites are primarily excreted via renal clearance (urinary excretion of phenolic conjugates), while SCFAs and residual polysaccharides are absorbed and either oxidized or exhaled as CO₂. Half-life for most active acids is approximately 2–3 hours, but residual hepatotonic effects persist beyond elimination due to transcriptional changes in hepatocyte detox enzymes.